The United States traditionally has had close relations with Venezuela, a major supplier of foreign oil, but there has been friction in relations for almost a decade under the government of populist President Hugo Chávez. U.S. officials have expressed concerns about human rights, Venezuela's military arms purchases, its relations with Cuba and Iran, and its efforts to export its brand of populism to other Latin American countries. Declining cooperation on anti-drug and anti-terrorism efforts has also been a concern.

Although Iran claims that its nuclear program is exclusively for peaceful purposes, it has generated considerable concern that Tehran is pursuing a nuclear weapons program. Indeed, the UN Security Council has responded to Iran's refusal to suspend work on its uranium enrichment and heavy-water nuclear reactor programs by adopting several resolutions which imposed sanctions on Tehran. Despite this pressure, Iran continues to enrich uranium, install and operate additional centrifuges, and conduct research on new types of centrifuges.

The Obama Administration views Iran as a major threat to U.S. national security interests, a perception generated not only by Iran's nuclear program but also by its materiel assistance to armed groups in Iraq and Afghanistan, to the Palestinian group Hamas, and to Lebanese Hezbollah. Throughout its first year, the Obama Administration altered the previous U.S. approach by offering Iran's leaders consistent and sustained engagement with the potential for closer integration with and acceptance by the West. To try to convince Iranian leaders of peaceful U.S.

Trafficking in people for prostitution and forced labor is one of the most prolific areas of international criminal activity and is of significant concern to the United States and the international community. The overwhelming majority of those trafficked are women and children. According to the most recent Department of State estimates, roughly 800,000 people are trafficked across borders each year. If trafficking within countries is included in the total world figures, official U.S. estimates are that some 2 to 4 million people are trafficked annually.

In 2002, the International Atomic Energy Agency (IAEA) began investigating allegations that
Iran had conducted clandestine nuclear activities; the agency ultimately reported that some of
these activities had violated Tehran?s IAEA safeguards agreement. The agency has not stated
definitively that Iran has pursued nuclear weapons, but has also not yet been able to conclude that
the country?s nuclear program is exclusively for peaceful purposes. The IAEA Board of
Governors referred the matter to the U.N. Security Council in February 2006.